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Mark Gladwin, lead investigator of the study, which was sponsored by the U.S. An estimated 70,000 to 100,000 people in the United States
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have this genetic blood disorder, most of them black. More than a third (38%) of those given the drug had severe side effects, mostly sickle cell pain crises,
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with 8% of people taking the placebo. "We wanted to test the drug in the way it would probably used in doctors' offices," Gladwin said. "It's the highest risk of death, so it's a very important complication,"
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It has a very high safety profile and has worked in every form of pulmonary hypertension. "It may be that we could use the drug in patients whose pain is controlled with either transfusions or hydroxyurea, although it's possible that the risk-benefit ratio would only play out in patients with higher pulmonary

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According to the institute, there are no current

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guidelines for treating pulmonary hypertension in people with sickle-cell disease, although drugs known as endothelin receptor blockers are sometimes
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on pulmonary hypertension. Sign Up for MedicineNet Newsletters. Pfizer, which makes Viagra and Revatio, provided the drug as well as the
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placebo for the trial. A small pilot trial using Revatio and involving just 12 people with sickle cell anemia had found a decrease in pulmonary hypertension. But the participants were also aggressively treated with
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The crises occur when red blood cells, which are misshaped

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"The patients in this trial had mild-to-moderate pulmonary hypertension." The investigators don't know why the trial produced the increased risk for pain crises, but they said there was no indication that the drug is not safe in other populations. News Articles Next Article.

In the multicenter trial that was stopped,

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